Exosomes
Many cellular proteins are involved in the biogenesis of exosomes.
Genomic health of the cells may favor or arrest some of the key regulators of exosome biogenesis.
Example
There is evidence of ESCRT (Endosomal Sorting Complexes Required for Transport) machinery implication in exosomes biogenesis.
GenSensor helps you document these variations to better understand the changes in ESCRT-coding genes.
By identifying specific biomarkers you’ll be able to retro control and boost your exosomes bioproduction.
As for ESCRT proteins, other signaling pathways that are implicated in exosomes biogenesis and release can be characterized at GenSensor.
Note that our biological analysis goes beyond cellular machinery to identify exosomes biomarkers (CD9, CD63, CD81, Annexin…), so you can characterize your final product.
Publications portfolio
Liu Q., Li, S, Dupuy, A., Mai, H.l., Sailliet, N., Logé, C., Robert, J.-M.H., Brouard, S., Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives. Int. J. Mol. Sci. 2021, 22, 7763. https://doi.org/10.3390/ ijms22157763
Yi X, Chen J, Huang D, Feng S, Yang T, Li Z, Wang X, Zhao M, Wu J and Zhong T (2022) Current perspectives on clinical use of exosomes as novel biomarkers for cancer diagnosis. Front. Oncol. 12:966981. doi: 10.3389/fonc.2022.966981