Many cellular proteins are involved in the biogenesis of exosomes.
Genomic health of the cells may favor or arrest some of the key regulators of exosome biogenesis.
Example:
There is evidence of ESCRT (Endosomal Sorting Complexes Required for Transport) machinery implication in exosomes biogenesis.
Since gene expression level is not constant during all the bioprocess and may be affected by many factors, ESCRT protein level vary throughout the bioproduction, which in turn affects:
- Exosomes concentration
- Batch-to-batch consistency
- Exosomes composition and quality
GenSensor helps you document these variations to better understand the changes in ESCRT-coding genes.
By identifying specific biomarkers you’ll be able to retro control and boost your exosomes bioproduction.
As for ESCRT proteins, other signaling pathways that are implicated in exosomes biogenesis and release can be characterized at GenSensor.
Note that our biological analysis goes beyond cellular machinery to identify exosomes biomarkers (CD9, CD63, CD81, Annexin…), so you can characterize your final product.
